Arfan 20/120

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Description

Arfan Tablet is a prescription medicine that is used to treat acute and uncomplicated malarial infections in patients weighing 5 kg (11 lb) and above. This medicine works by killing the parasitic organisms that cause malaria by blocking the synthesis of nucleic acid and proteins. This medicine helps by preventing the growth of malarial parasites.

When not to use
Arfan Tablet will not work to prevent malaria. Arfan will not work against patients who have severe or complicated malarial infections.
Antimalarial
Arfan belongs to the Antimalarial class of medicines. Antimalarial.

How to use

Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Arfan Tablet. If you have any questions related to this medicine, ask your doctor or pharmacist. Eat this medicine as recommended by your doctor.
Arfan Tablet is eaten with food. Infants and children who are unable to swallow the tablets, Arfan tablets must be crushed and mixed with a small amount of water (one to two teaspoons). If the patient vomits within 1 to 2 hours of taking the Arfan, a repeated dose of Arfan should be used. On the other hand, if the patient vomits the repeated dose, the patient should follow another alternative antimalarial for treatment.
The typical dose of Arfan is 80 mg/480 mg as a single initial dose, repeated as 80 mg/480 mg after 8 hours in a day and then followed by four doses (80 mg/480 mg) twice daily for the following two days. The usual dose for children is 20 mg/120 mg as a single initial dose, repeated as 20 mg/120 mg after 8 hours in a day and then followed by one dose (20 mg/120 mg) twice daily for the following two days. The maximum adult dose of Arfan is 160 mg/960 mg in a day.

You should continue to use this medicine as directed by the doctor even if you feel well.
Talk to your doctor if your condition does not improve or worsens. Tell your doctor if fever, chills (cold), muscle pain, and headache.
If you are giving Arfan Tablet to a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child’s weight or age to find the right dose from the product package. You can also read the dosage section of this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.

Avoid grapefruit juice while using Arfan. Grapefruit juice increases the amount of medicine in the blood.
You should store Arfan Tablet 15°C-30°C (59°F-86°F), and away from moisture. Store the medicine away from the reach of children and pets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not use Arfan Tablet for conditions for which it was not prescribed. Do not give Arfan Tablet to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.

How to take Arfan

The dose and frequency of using Arfan will depend on the following factors:
  • age of the patient
  • the weight of the patient
  • patient’s health
  • medicines recommended by the doctor
  • any other medicines being used
  • herbal supplements being used
  • response to the medicine

Arfan Dosage

Dosage for acute and uncomplicated malarial infections in patients weighing 5 kg (11 lb) and above

Adult (adult patients with a body weight of 35 kg (77 lb) and above)
  • Recommended: 80 mg/480 mg as a single initial dose, repeated as 80 mg/480 mg after 8 hours in a day and then followed by 80 mg/480 mg twice daily for the following two days
Children (children with a body weight of 5 kg (11 lb) to less than 15 kg (33.1 lb))
  • Recommended: 20 mg/120 mg as a single initial dose, repeated as 20 mg/120 mg after 8 hours in a day and then followed by one dose (20 mg/120 mg) twice daily for the following two days
Children (children with a body weight of 15 kg (33.1 lb) to less than 25 kg (55.1 lb))
  • Recommended: 40 mg/240 mg as a single initial dose, repeated as 40 mg/240 mg after 8 hours in a day and then followed by one dose (40 mg/240 mg) twice daily for the following two days
Children (children with a body weight of 25 kg (55.1 lb) to less than 35 kg (77.2 lb))
  • Recommended: 60 mg/360 mg as a single initial dose, repeated as 60 mg/360 mg after 8 hours in a day and then followed by one dose (60 mg/360 mg) twice daily for the following two days
Children (children with body weight of 35 kg (77.2 lb) and above)
  • Recommended: 80 mg/480 mg as a single initial dose, repeated as 80 mg/480 mg after 8 hours in a day and then followed by one dose (80 mg/480 mg) twice daily for the following two days

Minimum Age

2 months

Dosage calculation for children

To calculate the dosage for children please use the weight based dose calculator to calculate the appropriate dosage as per the weight of your child.

Precautions while using Arfan

Before you use Arfan, tell your doctor if you are allergic to it or its ingredients. Your doctor may prescribe an alternative medicine and update your medical records to record this information.
Before you use Arfan Tablet, tell your doctor of your medical history including prolonged heartbeat (QT prolongation), low blood potassium level, decreased heart rate (bradycardia), or heart attack (myocardial ischemia).

he use of Arfan Tablet may change platelet count. Use of Arfan may increase or decrease the number of the platelet count.
The use of this medicine may change white blood cell count. Use of Arfan can lead to increased or decreased the level of white blood cell count.
The use of Arfan Tablet may change alanine transaminase level. The level of alanine transaminase has been found to increase on treatment with Arfan.
The use of this medicine may change haematocrit level. Use of Arfan can lead to a decrease in the ratio of the volume of red blood cells (hematocrit level).
The use of this medicine may change aspartate aminotransferase level. The level of aspartate aminotransferase has been found to be increased during treatment with Arfan.
Arfan Tablet should be used only when required in patients who are pregnant or planning to become pregnant. Use this medicine only if the potential benefit outweighs the potential risk to the fetus. Consult with your doctor on the use of Arfan Tablet during breastfeeding. It is unknown wheter Arfan passes into breast milk. Consult with your doctor on the use of Arfan Tablet, if you are trying to conceive.
Arfan can make you feel sleepy. Be careful, especially while driving, while using heavy machinery, or when doing any activity that needs you to be completely alert. The consumption of alcohol with Arfan can worsen the sleepiness.

What precautions should be taken during Pregnancy and Nursing, and administering Arfan to Children or the Older Adults?

Pregnant Women

Only When Necessary
Warning: Use this medicine only if the potential benefit outweighs the potential risk to the fetus.

Breastfeeding

Precaution
Warning: It is not known whether Arfan passes into breast milk, use this medicine only if the potential benefit justifies the potential risk to the infant.

Younger Adults Population

Possibly safe
Warning: The effectiveness and safety data of Arfan have been established in children weighing 5 kg or more, but the safety and efficacy data have not been established in children who weigh less than 5 kg.

Older Adults Population

No Known Risk
Warning: No specific pharmacokinetic investigations have been conducted in patients older than 65 years.

Arfan Side-effects

The following side-effects may commonly occur when using Arfan Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
  • a cough
  • common cold (nasopharyngitis)
  • dizziness
  • fever
  • headache
  • insomnia
  • irritation and inflammation of the mucous membrane in the nose (rhinitis)
  • lack of energy
  • pain in joints (arthralgia)
  • pain in muscles
  • palpitations
  • rash
  • serious eating disorder (anorexia)
  • severe inflammatory blisters (acrodermatitis)
  • vomiting

Your doctor has prescribed Arfan Tablet because they judge that the benefit is greater than the risk posed by side-effects. Many people using this medicine do not have serious side-effects. This page does not list all possible side-effects of Arfan Tablet.

Mild Allergic Reactions

Following are the symptoms of mild allergic reactions to this medicine:
  • angioedema
  • pruritus
  • rash
  • urticaria

Serious Allergic Reactions

Following are the symptoms of serious allergic reactions to this medicine:
  • fluid filled blistering due to a side-effect to certain drugs (bullous eruption)
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice.

Warnings

Parasitic infection (Plasmodium vivax infection)

Recurring malaria caused by P. vivax requires additional therapy with other antimalarial agents to obtain complete removal of malarial parasites from the body (radical cure).

Kidney damage

Take necessary precautions while using Arfan in patients with severe kidney damage. In these patients, it is advised to monitor ECG and blood potassium levels.

Liver Damage

Caution should be used in dosing patients with severe liver damage. In these patients, it is advised to monitor ECG and blood potassium levels.

First trimester of pregnancy

Arfan should not be used in pregnancy (first trimester) in situations where other proper and adequate antimalarials are available.

Expired Medication

Taking a single dose of expired Arfan is unlikely to cause a side-effect. However, please discuss with your doctor or pharmacist, if you feel unwell or sick. An expired medicine may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use an expired drug. You are much safer by always keeping a fresh supply of unexpired medicines.

Additional information

SELECT STRENGTH

ARTEMETHER 20MG/ LUMEFANTRINE 120MG

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