D-Mannose is a naturally occurring simple sugar that is metabolized only in small amounts by the body, with the remainder being rapidly excreted with the urine. In the urinary tract, D-Mannose interferes with particle attachment and allows everything to be flushed out in the urine stream.* Clinical studies have demonstrated that when taken regularly, D-Mannose can help to maintain a healthy urinary tract.* Because insubstantial amounts of D-Mannose are used by the body, it does not interfere with healthy blood sugar regulation.
How does it work?
D-mannose might treat the deficiency caused by a genetic defect that causes abnormal breakdown and production of mannose. D-mannose might prevent certain kinds of bacteria from sticking to the walls of the urinary tract and causing infection.
Uses & Effectiveness
Likely Effective for
- An inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b. Taking d-mannose can improve digestive problems, low blood sugar, and blood clotting disorders in people with this disorder. D-mannose might also improve liver disease in some, but not all, people with this condition.
Insufficient Evidence for
- Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs). Early research shows that taking d-mannose for 13 days might reduce symptoms of UTIs, such as burning and increased urination. Early research also shows that taking d-mannose powder for 6 months after a UTI might help to prevent UTIs from occurring again.
- Other conditions.
Side Effects & Safety
When taken by mouth: D-mannose is POSSIBLY SAFE for most adults when taken in appropriate amounts for up to 6 months. It can cause diarrhea. In high doses, it might harm the kidneys. There isn’t enough reliable information to know if d-mannose is safe or what the side effects might be when taken by mouth, long-term.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn’t enough reliable information to know if d-mannose is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Children: D-mannose is POSSIBLY SAFE when taken by mouth in children with an inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b. It can cause diarrhea, loose stools, bloating, and nausea in these children. There isn’t enough reliable information to know if d-mannose is safe to use in children who do not have this condition.
Diabetes: D-mannose might make blood sugar control more difficult in people with diabetes.
The following doses have been studied in scientific research:
- For an inherited disorder called carbohydrate-deficient glycoprotein syndrome type 1b: 100-170 mg of d-mannose taken 3-6 times per day for a total daily dose of 300-1020 mg/kg has been used.